{"id":3395,"date":"2021-02-18T12:19:09","date_gmt":"2021-02-18T12:19:09","guid":{"rendered":"https:\/\/sepha.test\/?post_type=test-methods&#038;p=3395"},"modified":"2024-03-14T08:19:45","modified_gmt":"2024-03-14T08:19:45","slug":"vacuum-decay","status":"publish","type":"test-methods","link":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/","title":{"rendered":"Vacuum Decay"},"content":{"rendered":"<p><strong>The Vacuum Decay Leak Test method explained<\/strong><\/p>\n<p>The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI). The method can be used to identify gross defects in pharmaceutical, medical device and food packaging and micron leaks that are invisible to the human eye.<\/p>\n<p>Vacuum decay leak testing is an approved ASTM F2339-09 (2020) method and is a PDA recognized consensus standard for non-destructive detection of leaks in packages. While the ASTM standard for vacuum decay testing has been developed using the Veripac machine, different manufacturers offer vacuum decay leak test solutions based on the same principles outlined in the standard.<\/p>\n<p><strong>How does vacuum decay testing work?<\/strong><br \/>\nTo conduct a vacuum decay test, a container is placed in a tightly fitted chamber which is evacuated to a predetermined level of vacuum. After reaching the pre-set vacuum, a sensor measures the vacuum level over a predetermined time.<\/p>\n<p>If the integrity of the container under test has been compromised (it has a leak), there will be a rise in pressure inside the container. This will either result in not reaching the pre-set vacuum level, or the vacuum level will drop below a pre-set limit during the predetermined test time. This is due to air inside the container escaping into the tightly fitted chamber, in the form of gas, creating a pressure differential. The vacuum sensor monitors the change in pressure and indicates a leak is present in the container.<\/p>\n<p><strong>What type of containers can typically be tested using vacuum decay?<br \/>\n<\/strong>The vacuum decay test method can be used to test an array of non-porous flexible, rigid and semi-rigid packaging. Non-lidded trays and trays and cups sealed with non-porous lidding material can be tested if they can be masked or blocked during testing to create a vacuum chamber. Only then can a change in pressure inside the chamber, because of gas or vapor escaping, be measured.<\/p>\n<p>Packages that can be tested utilizing the vacuum decay test method include (but are not limited to):<\/p>\n<ul>\n<li>Rigid, non-porous containers including:\n<ul>\n<li>Plastic screw capped bottles containing solids (tablets, capsules, powders) or liquids (with significant gas headspace volume)<\/li>\n<li>Glass or plastic vials containing liquids (with significant gas headspace volume) or solids (powders)<\/li>\n<li>Glass or plastic ampoules containing liquids<\/li>\n<li>Glass pre-filled syringes containing liquids or solids (lyophilized powders)<\/li>\n<li>Ophthalmic dropper tip bottles containing liquids<\/li>\n<li>Blow Fill Seal bottle or strip containing liquid<\/li>\n<\/ul>\n<\/li>\n<li>Flexible, non-porous packages including bags and pouches containing solids (powders, medical devices)<\/li>\n<li>Sealed cups or trays containing solids (tablets, capsules, powder or devices)<\/li>\n<li>Non-lidded, empty cups or trays<\/li>\n<\/ul>\n<p><strong>USP 1207<br \/>\n<\/strong>Vacuum decay testing is also referenced in the revised USP 1207 guidance in which deterministic methods are preferred over probabilistic procedures such as the bubble test or blue bath method. The revised chapter will be applied to vials, ampoules, syringes, and bags.<\/p>\n","protected":false},"parent":0,"menu_order":0,"template":"","acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v22.5 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Vacuum decay leak test | Vacuum decay test method explained<\/title>\n<meta name=\"description\" content=\"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Vacuum decay leak test | Vacuum decay test method explained\" \/>\n<meta property=\"og:description\" content=\"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).\" \/>\n<meta property=\"og:url\" content=\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/\" \/>\n<meta property=\"og:site_name\" content=\"Sepha\" \/>\n<meta property=\"article:modified_time\" content=\"2024-03-14T08:19:45+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"6 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/\",\"url\":\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/\",\"name\":\"Vacuum decay leak test | Vacuum decay test method explained\",\"isPartOf\":{\"@id\":\"https:\/\/sepha.com\/#website\"},\"datePublished\":\"2021-02-18T12:19:09+00:00\",\"dateModified\":\"2024-03-14T08:19:45+00:00\",\"description\":\"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).\",\"breadcrumb\":{\"@id\":\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/sepha.com\/test-methods\/vacuum-decay\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/sepha.com\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Vacuum Decay\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/sepha.com\/#website\",\"url\":\"https:\/\/sepha.com\/\",\"name\":\"Sepha\",\"description\":\"Innovators of specialised equipment for non-destructive leak testing, blister packing and deblistering.\",\"publisher\":{\"@id\":\"https:\/\/sepha.com\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/sepha.com\/?s={search_term_string}\"},\"query-input\":\"required name=search_term_string\"}],\"inLanguage\":\"en-GB\"},{\"@type\":\"Organization\",\"@id\":\"https:\/\/sepha.com\/#organization\",\"name\":\"SEPHA\",\"url\":\"https:\/\/sepha.com\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-GB\",\"@id\":\"https:\/\/sepha.com\/#\/schema\/logo\/image\/\",\"url\":\"https:\/\/sepha.com\/app\/uploads\/2021\/03\/cropped-sepha-icon.png\",\"contentUrl\":\"https:\/\/sepha.com\/app\/uploads\/2021\/03\/cropped-sepha-icon.png\",\"width\":512,\"height\":512,\"caption\":\"SEPHA\"},\"image\":{\"@id\":\"https:\/\/sepha.com\/#\/schema\/logo\/image\/\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Vacuum decay leak test | Vacuum decay test method explained","description":"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/","og_locale":"en_GB","og_type":"article","og_title":"Vacuum decay leak test | Vacuum decay test method explained","og_description":"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).","og_url":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/","og_site_name":"Sepha","article_modified_time":"2024-03-14T08:19:45+00:00","twitter_card":"summary_large_image","twitter_misc":{"Estimated reading time":"6 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/","url":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/","name":"Vacuum decay leak test | Vacuum decay test method explained","isPartOf":{"@id":"https:\/\/sepha.com\/#website"},"datePublished":"2021-02-18T12:19:09+00:00","dateModified":"2024-03-14T08:19:45+00:00","description":"The vacuum decay leak test is a non-destructive test method used to detect leaks in packaging to ensure container closure integrity (CCI).","breadcrumb":{"@id":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/#breadcrumb"},"inLanguage":"en-GB","potentialAction":[{"@type":"ReadAction","target":["https:\/\/sepha.com\/test-methods\/vacuum-decay\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/sepha.com\/test-methods\/vacuum-decay\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/sepha.com\/"},{"@type":"ListItem","position":2,"name":"Vacuum Decay"}]},{"@type":"WebSite","@id":"https:\/\/sepha.com\/#website","url":"https:\/\/sepha.com\/","name":"Sepha","description":"Innovators of specialised equipment for non-destructive leak testing, blister packing and deblistering.","publisher":{"@id":"https:\/\/sepha.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/sepha.com\/?s={search_term_string}"},"query-input":"required name=search_term_string"}],"inLanguage":"en-GB"},{"@type":"Organization","@id":"https:\/\/sepha.com\/#organization","name":"SEPHA","url":"https:\/\/sepha.com\/","logo":{"@type":"ImageObject","inLanguage":"en-GB","@id":"https:\/\/sepha.com\/#\/schema\/logo\/image\/","url":"https:\/\/sepha.com\/app\/uploads\/2021\/03\/cropped-sepha-icon.png","contentUrl":"https:\/\/sepha.com\/app\/uploads\/2021\/03\/cropped-sepha-icon.png","width":512,"height":512,"caption":"SEPHA"},"image":{"@id":"https:\/\/sepha.com\/#\/schema\/logo\/image\/"}}]}},"_links":{"self":[{"href":"https:\/\/sepha.com\/wp-json\/wp\/v2\/test-methods\/3395"}],"collection":[{"href":"https:\/\/sepha.com\/wp-json\/wp\/v2\/test-methods"}],"about":[{"href":"https:\/\/sepha.com\/wp-json\/wp\/v2\/types\/test-methods"}],"wp:attachment":[{"href":"https:\/\/sepha.com\/wp-json\/wp\/v2\/media?parent=3395"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}